Advice for male patients taking Valproate

This information is male patients taking valproate as well as their families and caregivers. Always read the information that comes with your medicine and talk to a doctor, nurse, or pharmacist if you have any concerns.

It is important that you do not stop or reduce your medication, unless advised to do so by a healthcare professional.

The Medicines and Healthcare products Regulatory Agency (MHRA) has issued advice for male patients taking Sodium Valproate. Valproate is a medication used to help manage epilepsy and some mood disorders. Brand names include Epilim and Depakote.

The MHRA has advised that studies have shown a potential small increased risk of neurodevelopmental problems for children conceived whilst the father is taking Valproate, or has taken it in the last 3 months.

Advice for men taking Valproate

It is recommended that you and your female sexual partner should both use effective birth control (condoms and another form of female contraception) as a precaution while you are taking valproate and for at least 3 months after stopping valproate.
Let your doctor know if you are planning to father a child and are on valproate.
Allow at least 3 months to pass after stopping valproate before trying to father a child.
You should not donate sperm whilst taking valproate and for 3 months after stopping.
Do not stop taking valproate or reduce the dose unless you are advised to do so by your specialist.
Attend your next appointment, when invited to do so, to discuss the risks and your options.